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Receptors · Review pending

GLP1R

Glucagon-like peptide 1 receptor

Class B1 G protein-coupled receptor · Homo sapiens

Primary signalling route

  • Gs → adenylyl cyclase → cAMP

This describes receptor biology; it does not establish the signalling profile of every ligand.

Receptor location — biological context

A receptor in an organ does not prove that this compound reaches or affects that organ.

  • PancreasHomo sapiens · non-human primatesPyke et al., 2014

    A tissue study localized pancreatic GLP1R mainly to beta cells. These cells release insulin. Receptor location is biological context, not proof of a drug effect.

  • KidneysHomo sapiens · non-human primatesPyke et al., 2014

    In this human and monkey tissue study, GLP1R was detected in smooth muscle of renal arteries and arterioles. This does not establish receptor expression throughout the kidney or explain a particular drug’s clinical kidney outcomes.

  • HeartHomo sapiens · non-human primatesPyke et al., 2014

    The study localized GLP1R to muscle cells of the sinoatrial node, a region involved in setting heart rhythm. This is a finding in a specific cell population, not the whole heart.

  • StomachHomo sapiens · non-human primatesPyke et al., 2014

    The tissue study detected GLP1R in parietal cells and smooth muscle cells in the outer muscle layer of the stomach. Location alone does not measure a molecule’s effect on gastric emptying.

  • Small intestineHomo sapiens · non-human primatesPyke et al., 2014

    Within the gastrointestinal tissues studied, GLP1R expression was highest in Brunner’s glands of the duodenum. The study also found it in myenteric neurons throughout the gut.

Molecules with a mapped relationship

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