Nootropic & Neuropeptides

9-Methyl-Beta-Carboline

9-ME-BC is included for complete PeptideGuide catalog coverage. Identity, evidence, regulatory status and safety claims are awaiting independent verification.

NA-Semax-Amidate (Enhanced)

Adamax is included for complete PeptideGuide catalog coverage. Identity, evidence, regulatory status and safety claims are awaiting independent verification.

L-Alpha glycerylphosphorylcholine

Alpha-GPC is included for complete PeptideGuide catalog coverage. Identity, evidence, regulatory status and safety claims are awaiting independent verification.

Bromantan, Ladasten, Adamantylbromphenylamine

Bromantane is a synthetic non-peptide aminoadamantane marketed by prescription as Ladasten in Russia for asthenic states and neurasthenia. Russian human studies exist, but the controlled trials are small, old and at risk of bias; it is not FDA-approved or centrally authorised in the EU and is prohibited in competition by WADA under S6.A.

FPF-1070, Cerebrolysin peptide preparation

A standardized mixture of low-molecular-weight peptides and free amino acids derived from purified porcine brain proteins, marketed by EVER Pharma in some countries as a neurotrophic agent and studied in ischemic stroke, dementia, and traumatic brain injury. It is not FDA- or EMA-approved, and systematic reviews report mixed and disputed evidence.

AEDP, Ala-Glu-Asp-Pro, H-Ala-Glu-Asp-Pro-OH, Cortagen tetrapeptide

A synthetic tetrapeptide (Ala-Glu-Asp-Pro, "AEDP") from Vladimir Khavinson's "short peptide bioregulator" school, derived by directed synthesis from the cerebral-cortex preparation cortexin and marketed as a brain/nervous-system "bioregulator." Evidence is limited, older, and almost entirely from the Khavinson lineage — rodent nerve-regeneration and ex-vivo chromatin studies, with no published human clinical trials. Not approved for human use.

Кортексин

A Russian prescription preparation containing a heterogeneous mixture of polypeptides obtained from cattle brain cortex. It is not a single sequence-defined peptide. Human trials exist, but systematic reviews judge the independent evidence limited and at important risk of bias.

N-hexanoyl-Tyr-Ile-(6)-aminohexanamide

Dihexa is a synthetic angiotensin-IV-derived peptide mimetic studied in cells and animals as a modulator of HGF/c-Met signalling; human efficacy and safety have not been established.

Delta sleep-inducing peptide, Delta EEG-inducing peptide

A naturally occurring nonapeptide isolated in 1977 from the cerebral venous blood of sleeping rabbits. Despite its name, its sleep-promoting effects are inconsistent across studies and its physiological role, biosynthetic origin, and receptor remain unestablished. The evidence base is old, mixed, and largely preclinical.

FGL Peptide (NCAM Mimetic)

FGL is included for complete PeptideGuide catalog coverage. Identity, evidence, regulatory status and safety claims are awaiting independent verification.

Omberacetam, GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester

Noopept is a synthetic prolylglycine-derived small molecule with limited, mostly Russian-language clinical literature and a larger preclinical literature; robust human efficacy and safety are not established.

Hypocretin-1

Orexin-A is included for complete PeptideGuide catalog coverage. Identity, evidence, regulatory status and safety claims are awaiting independent verification.

P-21, P21, Peptide 021

P021 is an engineered CNTF-derived tetrapeptide-core compound with a terminal adamantylated-glycine modification. Published evidence remains preclinical, no human intervention study was identified, and recent records include a mixed 2024 animal result, a 2026 corrigendum and a retraction in the related CNTF-peptide research line.

Pituitary Adenylate Cyclase-Activating Polypeptide

PACAP is included for complete PeptideGuide catalog coverage. Identity, evidence, regulatory status and safety claims are awaiting independent verification.

EDR, EDR peptide, Glu-Asp-Arg, Cortagen-family cytogen

A synthetic tripeptide (Glu-Asp-Arg, "EDR") from Vladimir Khavinson's St. Petersburg school of short peptide bioregulators, marketed with a nootropic/neuroprotective framing. Its chemistry is well defined, but efficacy claims rest on cell, rodent, and limited, older, single-group human data with no independent replication. Not approved by the FDA or EMA for any use.

Ginsenoside-Derived Neuro-Peptide

RG-3 is included for complete PeptideGuide catalog coverage. Identity, evidence, regulatory status and safety claims are awaiting independent verification.

TP-7

A synthetic heptapeptide analog of the endogenous immunopeptide tuftsin, studied largely in Russian research for anxiolytic, nootropic, and immunomodulatory effects. Not approved by the FDA or EMA.

ACTH(4-10) Pro-Gly-Pro analog, ACTH(4-7)PGP, Met-Glu-His-Phe-Pro-Gly-Pro

A synthetic heptapeptide derived from a fragment of ACTH, developed and registered in Russia and studied for nootropic and neuroprotective effects, with research most often linking it to BDNF signaling. Most evidence is Russian and not replicated in large Western trials.