Signal atlas
Structured, source-bound maps of which biologically active molecules engage which targets — with pharmacology, evidence level, and explicit boundaries against clinical inference.
12 linked monographs
Incretin–glucagon axis
A source-bound map of mature human GLP-1, GIP and glucagon ligands, their class B1 receptors, and a separate receptor-level layer for five engineered agonists.
4 molecules · 5 engineered agonists · 3 targets · 15 verified relations
Amylin–calcitonin/RAMP axis
A source-bound map of mature human amylin, the CALCR/RAMP-defined AMY1–AMY3 receptor complexes, the calcitonin receptor, and separate receptor-level evidence for pramlintide and cagrilintide.
1 molecules · 2 engineered agonists · 4 targets · 10 verified relations
Acyl-ghrelin–GHSR axis
A source-bound map of octanoylated human ghrelin-28, the human GHS-R1a receptor and its primary Gq/11 route, with separate target evidence for the peptide research ligand GHRP-6 and the non-peptide investigational compound ibutamoren.
1 molecules · 2 engineered agonists · 1 targets · 3 verified relations
Alpha-MSH–melanocortin axis
A source-bound map of mature human alpha-MSH, its MC1R, MC3R, MC4R and MC5R agonist relations, and separate human-target evidence for afamelanotide, bremelanotide and Melanotan II.
1 molecules · 3 engineered agonists · 4 targets · 16 verified relations