Is HGF approved as a medicine, and where?

The regulatory review of HGF is incomplete. See the article's sources for product- and country-specific findings and remaining uncertainties. Review status means neither worldwide approval nor worldwide absence of approval.

What is HGF studied for?

HGF is most often discussed in the context of cognition, mood & sleep. Being studied for an area does not mean it is proven or approved for it.

Does HGF have human clinical trials?

The evidence review of HGF is in progress. The article's study appraisal identifies any human studies located and their limitations. An ongoing review does not itself mean that human studies are absent.

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Nootropic & Neuropeptides

HGF

1 min read · Updated September 14, 2026 · 2 references

Curated by PeptideInfo Wikilast reviewed September 14, 2026how we verify

Explored forCognition, mood & sleep

HGF, hepatocyte growth factor, is also known as scatter factor.

Body & signals →

No receptor relationship mapped here yet. This does not mean the molecule has no biological effects.

Review pending

Contents3

Section 1 of 3What is it?

What is it?

HGF, hepatocyte growth factor, is also known as scatter factor. The active protein contains disulfide-linked alpha and beta chains and activates the receptor tyrosine kinase MET. Despite its liver-related name, its biology extends to multiple tissues. C01 (opens in a new tab)

Section 2 of 3What was studied?

What was studied?

The original receptor work compared purified scatter factor and HGF in cell assays. Both promoted growth, motility and invasion, bound the same sites, and induced MET phosphorylation. These experiments established a ligand–receptor relationship; they did not test memory improvement in people. C02 (opens in a new tab)

Section 3 of 3What does the result mean?

What does the result mean?

Growth, survival and migration are different cellular outcomes. Their value depends on the tissue and disease context; more signaling is not automatically better. Follow the HGF–MET guide before interpreting claims about Dihexa. Evidence for HGF itself cannot substitute for experiments on that compound. C03 (opens in a new tab)

References2

References

1.
UniProt P14210 — human hepatocyte growth factor source
2.
Naldini et al., 1991 — scatter factor and HGF are MET ligands source

Frequently asked questions4

Frequently asked questions

What is HGF?: HGF, hepatocyte growth factor, is also known as scatter factor.
Is HGF approved as a medicine, and where?: The regulatory review of HGF is incomplete. See the article's sources for product- and country-specific findings and remaining uncertainties. Review status means neither worldwide approval nor worldwide absence of approval.
What is HGF studied for?: HGF is most often discussed in the context of cognition, mood & sleep. Being studied for an area does not mean it is proven or approved for it.
Does HGF have human clinical trials?: The evidence review of HGF is in progress. The article's study appraisal identifies any human studies located and their limitations. An ongoing review does not itself mean that human studies are absent.

Educational disclaimer. This article summarizes published research for informational purposes and is not medical advice. The editorial review of HGF is incomplete. Source-supported findings and remaining uncertainties are stated in the article; review status does not certify approval, safety or suitability for use. Consult a qualified healthcare professional before making health decisions.