HGF, also called scatter factor, binds MET. Original cell experiments connected ligand binding with receptor phosphorylation, growth and motility. This map describes the endogenous ligand and receptor; it does not rank therapies. Primary study (opens in a new tab).
Active HGF consists of alpha and beta chains. The sequence display joins them in precursor order for reference; the cleavage and disulfide-linked structure remain essential. The MET component length refers to the canonical precursor protein, not an isolated receptor domain. HGF record (opens in a new tab) · MET record (opens in a new tab).
MET connects to several intracellular pathways. Growth, survival and migration must be interpreted in the relevant tissue and disease context. A proposed modulator is not necessarily a direct receptor agonist. Dihexa therefore remains a separate article rather than an assumed direct-agonist arrow in this map. Evidence for HGF biology alone does not establish that compound’s human benefit. MET signaling (opens in a new tab).